Treatment with Deferiprone for Iron Overload Alleviates Bone Marrow Failure in a Fanconi Anemia Patient

Yu-Hsiang Chang Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan; Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan

Chen-Fu Shaw Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan

Kang-Hsi Wu Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan

Kai-Hsien Hsieh Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Yi-Ning Su Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan

Pei-Jung Lu Institute of Clinical Medicine, School of Medicine, National Cheng Kung University, Tainan, TaiwanCorrespondence[email protected] [email protected]

Abstract

Fanconi anemia (FA) is a rare inherited disorder characterized by congenital abnormalities, progressive bone marrow failure and cancer susceptibility. There are no reports in the literature about a specific therapy effective in treating the progressive bone marrow failure of FA except for hematopoietic stem cell transplantation (HSCT). A FA patient started to receive deferiprone (L1) therapy due to iron overload. We report here that the white blood cell counts, hemoglobin (Hb) levels and platelet counts were significantly higher during the L1-treated period than when without L1 therapy. Therefore, L1 therapy may be worth considering for FA patients who cannot undergo HSCT.

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Declaration of Interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

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Treatment with Deferiprone for Iron Overload Alleviates Bone Marrow Failure in a Fanconi Anemia Patient

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Treatment with Deferiprone for Iron Overload Alleviates Bone Marrow Failure in a Fanconi Anemia Patient

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