Another Form of tie Hereditary Persistence of Fetal Hemoglobin (The Atlanta Type)?

C. Altay Laboratory of Protein Chemistry, Department of Cell and Molecular Biology and Comprehensive Sickle Cell Center, Medical College of Georgia and Veterans Administration Hospital, Augusta, Georgia, 30902, USA; Division of Chemistry and Chemical Engineering (Contribution No. 5394), California Institute of Technology, Pasadena, California, 91125, USA

T. H. J. Huisman Laboratory of Protein Chemistry, Department of Cell and Molecular Biology and Comprehensive Sickle Cell Center, Medical College of Georgia and Veterans Administration Hospital, Augusta, Georgia, 30902, USA; Division of Chemistry and Chemical Engineering (Contribution No. 5394), California Institute of Technology, Pasadena, California, 91125, USA

W. A. Schroeder Laboratory of Protein Chemistry, Department of Cell and Molecular Biology and Comprehensive Sickle Cell Center, Medical College of Georgia and Veterans Administration Hospital, Augusta, Georgia, 30902, USA; Division of Chemistry and Chemical Engineering (Contribution No. 5394), California Institute of Technology, Pasadena, California, 91125, USA

Abstract

The propositus in a Black family has elevated Hb-F and approximately equal amounts of Hb-A and Hb-S. Hematological and chemical studies of the propositus and his family show elevated Hb-F in the father and a sibling and sickle cell trait in the mother and another sibling. This family is believed to have a form of the hereditary persistence of fetal hemoglobin in which β chains are produced in cis to the determinant.

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Another Form of tie Hereditary Persistence of Fetal Hemoglobin (The Atlanta Type)?

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Another Form of tie Hereditary Persistence of Fetal Hemoglobin (The Atlanta Type)?

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