Hb-Alberta or α₂β₂ (101(G3) GLU→GLY), a New High-Oxygen-Affinity Hemoglobin Variant Causing Erythrocytosis

M. J. Mant Division of Hematology, Department of Medicine, and Department of Laboratory Medicine, the University of Alberta, Edmonton, Alberta, Canada

M. L. Salkie Division of Hematology, Department of Medicine, and Department of Laboratory Medicine, the University of Alberta, Edmonton, Alberta, Canada

Nancy Cope Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Medical College of Georgia, Augusta, Ga, 30902, USA

Francine Appling Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Medical College of Georgia, Augusta, Ga, 30902, USA

Kathleen Bolch Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Medical College of Georgia, Augusta, Ga, 30902, USA

M. Jayalakshmi Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Medical College of Georgia, Augusta, Ga, 30902, USA

Marsha Gravely Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Medical College of Georgia, Augusta, Ga, 30902, USA

J. B. Wilson Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Medical College of Georgia, Augusta, Ga, 30902, USA

T. H. J. Huisman Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Medical College of Georgia, Augusta, Ga, 30902, USA

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Abstract

Hb-Alberta has been found in a 51 year old Caucasian male with erythrocytosis. The substitution in this variant involves the glutamyl residue in position lOl(G3) of the β chain which is replaced by a glycyl residue. Hb-Alberta accounts for about 45% in the heterozygote, and readily forms hybrid tetramers with other hemoglobins. The oxygen affinity of Hb-Alberta is greatly increased, its Bohr effect reduced, and its subunit interaction greatly diminished.

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Hb-Alberta or α₂β₂ (101(G3) GLU→GLY), a New High-Oxygen-Affinity Hemoglobin Variant Causing Erythrocytosis

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Hb-Alberta or α2β2 (101(G3) GLU→GLY), a New High-Oxygen-Affinity Hemoglobin Variant Causing Erythrocytosis

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Hb-Alberta or α₂β₂ (101(G3) GLU→GLY), a New High-Oxygen-Affinity Hemoglobin Variant Causing Erythrocytosis