Hemoglobin Baylor [α₂β₂81(EF5) Leu→ arc]-an Unstable Mutant with High Oxygen Affinity

Rose G. Schneider Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, 77550

Robert A. Hettig Baylor College of Medicine Methodist Hospital, Houston, Texas

Mary Bilunos Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, 77550

Bernadine Brimhall Department of Biochemistry, School of Medicine, University of Oregon Health Sciences Center, Portland, Oregon, 97201

Abstract

The amino acid substitution in a new homoglobin variant, Hb Baylor [α₂β₂81(EF5) Leu-Arg], has been determined by application of column chromatography and amino acid analysis of the tryptic peptides. The hemoglobin is somewhat unstable and it has a high oxygen affinity. The porosities shows the opposing hematologic effects of these two properties-the instituionability being associated with increased destruction, and the high O₂ affinity with increased production, of erythrocytes.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Hemoglobin Baylor [α₂β₂81(EF5) Leu→ arc]-an Unstable Mutant with High Oxygen Affinity

Information for

Open access

Opportunities

Help and information

Hemoglobin Baylor [α2β281(EF5) Leu→ arc]-an Unstable Mutant with High Oxygen Affinity

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature

Hemoglobin Baylor [α₂β₂81(EF5) Leu→ arc]-an Unstable Mutant with High Oxygen Affinity