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Hemoglobin
international journal for hemoglobin research
Volume 1, 1977 - Issue 7
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Original Article

Variation in Hemoglobin A2

F. Vella Department of Biochemistry, College of Medicine, University of Saskatchewan, Saskatoon, Sask., Canada, S7N OW0
Pages 619-650 | Received 23 May 1977, Accepted 26 Jul 1977, Published online: 07 Jul 2009
 
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Abstract

The structure, properties and function of, and some bio-synthetic and genetic aspects of, Hb A2 are described. The structural variants of the A2 are reviewed and their geographical distribution presented. Hb A2', Hb A2-Flatbush and Hb A2-Babinga are characteristic of negro populations and may have originated in Western or Central Africa. Hb A2-Sphakia is characteristic of Canadian Amerindian and lib A2-Indonesia of Indonesian/Malay populations. Hb A2-NYU has only been found sporadically and most frequently in persons of Eastern European origin. The other three variants of Hb A2 have only been reported in a single person or in single families. Some conditions which are associated with changes in Hb A2 levels are reviewed.

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