β-Chain Variants in Jamaican Newborns

E. Ahern Department of Pathology, University of West Indies

V. Ahern Department of Pathology, University of West Indies

G. R. Serjeant The MRC Laboratories, University of West Indies

B. E. Serjeant The MRC Laboratories, University of West Indies

M. Seakins Department of Chemistry, University of West Indies, Kingston, Jamaica

P. Darbre Department of Clinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge

A. Middleton Department of Clinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge

H. Lehmann Department of Clinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge

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Abstract

In an electrophoretic study of 15,661 Jamaican cord bloods, 8 rare β-chain variants were found in 18 subjects in addition to the common β-chain variants, Hb S and Hb C. The heterozygote frequencies for Hb S and Hb C were 10.1% and 3.7% respectively. The most frequent of the rare β-chain variants were Hb Korle Bu (β 73 Asp → Asn) (7 cases) and Hb Osu-Christiansborg (β 52 Asp → Asn) (3 cases). One new B-chain variant, Hb Caribbean (8 91 Leu → Arg) was found.

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β-Chain Variants in Jamaican Newborns

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β-Chain Variants in Jamaican Newborns

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