Hemoglobins AIDA (α64 ASP → ASN) and D-Los Angeles (β121 Glu → Glu) in an Asian-Indian Family

H. F. Bunn Hematology Division, Department of Medicine, Peter Bent Brigham Hospital, Harvard Medical School, Boston, Mass, 02115; Investigator, Howard Hughes Medical Institute

A. J. Altman Division of Pediatric Hematology/Oncology, University of Connecticut Health Center, Farmington, CT

K. Stangland Hematology Section, Department of Medicine, Yale University School of Medicine, New Haven, CT

S. I. Firshein Department of Biochemistry, Health Sciences Center, University of Oregon, Portland, Oregon

B. Forget Department of Biochemistry, Health Sciences Center, University of Oregon, Portland, Oregon

G. J. Schmidt Hematology Division, Department of Medicine, Peter Bent Brigham Hospital, Harvard Medical School, Boston, Mass, 02115

R. T. Jones Hematology Section, Department of Medicine, Yale University School of Medicine, New Haven, CT

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Abstract

Hemoglobins D-Los Angeles (β 121 Gin) and Aida (α64 Asn) were encountered in an Asian Indian, unassociated with any clinical manifestations. These hemoglobins had normal oxygen affinities and were stable to heat and isopropanol. The ratio of α chain synthesis to β chain synthesis was close to unity. The identical change in isoelectric points of the two variants produced an interesting electrophoretic pattern.

The coexistance of more than one hemoglobin variant in an individual or family has provided valuable

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Hemoglobins AIDA (α64 ASP → ASN) and D-Los Angeles (β121 Glu → Glu) in an Asian-Indian Family

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Hemoglobins AIDA (α64 ASP → ASN) and D-Los Angeles (β121 Glu → Glu) in an Asian-Indian Family

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