Hemoglobin J Altgeld Gardens A Hemoglobin Variant with A Substitution of the Proximal Histidinf the β-Chain

Junius G. Adams Veterans Administration West Side Hospital, and the Departments of Medicine and Pediatrics, University of Illinois Abraham Lincoln School of Medicine, Chicago, IL

Kenneth P. Przywara Veterans Administration West Side Hospital, and the Departments of Medicine and Pediatrics, University of Illinois Abraham Lincoln School of Medicine, Chicago, IL

Paul Heller Veterans Administration West Side Hospital, and the Departments of Medicine and Pediatrics, University of Illinois Abraham Lincoln School of Medicine, Chicago, IL

Mir Shamsuddin Veterans Administration West Side Hospital, and the Departments of Medicine and Pediatrics, University of Illinois Abraham Lincoln School of Medicine, Chicago, IL

Abstract

Hemoglobin J Altgeld Gardens (β92 (F6) His→Asp) (Hb J^AG) was detected in a 21-year-old black female who also was heterozygous for β° thalassemia. Oxygen affinity of this variant was normal, but the Hill coefficient was slightly decreased. Despite the substitution of the proximal histidine molecular stability was only mildly impaired, methemoglobinemia was absent and the moderate anemia probably was not related to the abnormal hemoglobin.

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Hemoglobin J Altgeld Gardens A Hemoglobin Variant with A Substitution of the Proximal Histidinf the β-Chain

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Hemoglobin J Altgeld Gardens A Hemoglobin Variant with A Substitution of the Proximal Histidinf the β-Chain

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