Abstract
The occurrence of hemoglobin Potomac (8101 Glu→Asp), an abnormal hemoglobin with increased oxygen affinity, has been previously reported in nine members of one kindred (1). We now present the second occurrence of this hemoglobin, in a 26 year old white female of mixed northern European extraction, and report the clinical picture and studies of the stability and biosynthesis of the abnormal hemoglobin.