Double Heterozygoy for Hemoglobin Camden (β¹³¹ Gln → Glu) And Alpha Thalassemia

Abstract

During the course o f screening for abnormal hemoglobins in the City of New York, an abnormal hemoglobin with fast electrophoretic mobility was discovered in an asymptomatic 16-year-old Black female high school student. Structural studies, performed on the variant hemoglobin, demonstrated an amino acid substitution (B₁₃₁ Gln → Glu) which has been described previously as hemoglobin Camden (1,2,3). studies were indicated by the observation of approximately 45% Hb Camden in association with mild microcytosis and hypochromia, perhaps the suggestion of α-thalassemia.