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Hemoglobin
international journal for hemoglobin research
Volume 2, 1978 - Issue 2
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Original Article

Clinical and Hematological Studies in a Family with Hemoglobin Vancouver

G. R. Gray Departments of Medicine and Pathology, University of British Columbia and Vancouver General Hospital Vancouver, Canada, V5Z 1M9
&
R. B. Marion Departments of Medicine and Pathology, University of British Columbia and Vancouver General Hospital Vancouver, Canada, V5Z 1M9
Pages 143-152 | Received 17 Oct 1977, Accepted 19 Dec 1977, Published online: 07 Jul 2009
 
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Abstract

Hb Vancouver (α2β2 73 (E17) ASP→TYR) was found in combination with β°thalassemia trait in a Chinese male who presented with splenomegaly and thalassemia intermedia (3). The family study has revealed two members with β thalassemia trait, one heterozygote for Hb E, and two heterozygotes for Hb Vancouver. The Hb Vancouver heterozygotes were clinically normal but their erythrocytes showed reduced osmotic fragility and occasional target cells.

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