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Hemoglobin
international journal for hemoglobin research
Volume 3, 1979 - Issue 5
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Original Article

Preliminary Experiments in the Separation of Globin Chains by high Performance Liquid Chromatography

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Pages 353-358 | Received 16 Jul 1979, Accepted 09 Aug 1979, Published online: 07 Jul 2009
 

Abstract

The power of high performance liquid chromatography (HPLC) for the separation of complex mixtures of peptides from proteins is becoming increasingly evident (1–4 and references in 3). However, the application of HPLC to the separation of proteins is limited. Mönch and Dehnen (5) separated artificial mixtures of proteins (5,400 to 450,000 daltons) and Rubenstein et al. used HPLC to purify interferon (6). In preliminary experiments, we have had some success in the separation of human globin chains by HPLC.

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