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Hemoglobin
international journal for hemoglobin research
Volume 3, 1979 - Issue 2-3
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Original Article

Hemoglobin Sunshine Seth - α2(94 (G1) Asp→His)β2

W. A. Schroeder Division of Chemistry and Chemical Engineering,†, California Institute of Technology, Pasadena, CA, 91125; Darleen Powars Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, CA, 90033
,
Joan B. Shelton Division of Chemistry and Chemical Engineering,†, California Institute of Technology, Pasadena, CA, 91125; Darleen Powars Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, CA, 90033
&
J. Roger Shelton Division of Chemistry and Chemical Engineering,†, California Institute of Technology, Pasadena, CA, 91125; Darleen Powars Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, CA, 90033
Pages 145-159 | Received 10 Apr 1979, Accepted 03 May 1979, Published online: 07 Jul 2009
 
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Abstract

Hemoglobin Sunshine Seth in which a histidyl is substituted for an aspartyl residue at position 94 of the α chain was detected at birth in a Caucasian male infant during cord blood screening and is present also in the mother and a male sibling. Although the substitution is in the α1β2 contact, it is without obvious deleterious effect on the hematological parameters or the health of the affected individuals.

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