Hemoglobin Variants and Methods Used for Their Characterization During 7 Years of Screening at the Center for Disease Control

Winston F. Moo-Penn Hematology Division, Center for Disease Control, U. S. Public Health Service, Atlanta, Georgia, 30333

Danny L. Jue Hematology Division, Center for Disease Control, U. S. Public Health Service, Atlanta, Georgia, 30333

Mary H. Johnson Hematology Division, Center for Disease Control, U. S. Public Health Service, Atlanta, Georgia, 30333

Katherine C. Bechtel Hematology Division, Center for Disease Control, U. S. Public Health Service, Atlanta, Georgia, 30333

Leslie C. Patchen Hematology Division, Center for Disease Control, U. S. Public Health Service, Atlanta, Georgia, 30333

Abstract

During 7 years of screening for hemoglobin variants, over 75 rare variants have been characterized. Of these, 18 were described for the first time. This report presents tabulated data regarding the structural and functional defects that were observed, information on the ethnic origin, and other special properties exhibited by these variants. The strategy and procedures for characterizing these variants are also summarized.

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Hemoglobin Variants and Methods Used for Their Characterization During 7 Years of Screening at the Center for Disease Control

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Hemoglobin Variants and Methods Used for Their Characterization During 7 Years of Screening at the Center for Disease Control

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