Homozygous Delta Thalassemia in Japan

Y. Ohta First Department of Internal Medicine Faculty of Medicine, Ehime University, Ehime, Japan

M. Yasukawa First Department of Internal Medicine Faculty of Medicine, Ehime University, Ehime, Japan

S. Saito First Department of Internal Medicine Faculty of Medicine, Ehime University, Ehime, Japan

S. Fujita First Department of Internal Medicine Faculty of Medicine, Ehime University, Ehime, Japan

Y. Kobayashi First Department of Internal Medicine Faculty of Medicine, Ehime University, Ehime, Japan

Abstract

Six families with δ-thalassemia have been found in Japan, in which 10 individuals are δ-thalassemia homozygotes with complete deficiency of Hb A₂ and 18 individuals are heterozygotes with low levels of Hb A₂. In three families with 10 individuals among these, persistence of fetal hemoglobin of Swiss type was observed. Almost all the members of these families were free from clinical symptoms and hematological abnormalities of the red cells.

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Homozygous Delta Thalassemia in Japan

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Homozygous Delta Thalassemia in Japan

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