The Organization of the γ-δ-β Gene Complex in Normal and Thalassemia Cells

A. Bank Columbia University, Departments of Medicine and Human Genetics and Development New York, New York, 10032

J. G. Mears Albert Einstein College of Medicine, Department of Medicine, Bronx, New York, 10461

F. Ramirez Rutgers University, Department of Obstetrics and Gynecology Piscataway, New Jersey, 08854

A. L. Burns Columbia University, Departments of Medicine and Human Genetics and Development New York, New York, 10032

S. Spence Columbia University, Departments of Medicine and Human Genetics and Development New York, New York, 10032

J. Feldenzer Columbia University, Departments of Medicine and Human Genetics and Development New York, New York, 10032

M. Baird Columbia University, Departments of Medicine and Human Genetics and Development New York, New York, 10032

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Abstract

Restriction enzyme digestion analysis and direct human globin gene cloning have permitted analysis of the physical arrangement of nucleotide sequences within and surrounding the human globin genes. With these methods it has been shown that the linear arrangement 5′ to 3′ of the globin genes is ^Gγ-^Aγ-δ-β. The ^Gγ and ^Aγ genes are separated by about 3.5 kilobases (kb), while the ^Aγ and δ genes are 15 kb apart, and the δ and β 6.5 kb apart. Each of these genes contains a large intervening sequence (IVS) of approximately l kb in precisely the same position between codons 104 and 105. In addition, each of these genes has a small IVS between codons 30 and 31.

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The Organization of the γ-δ-β Gene Complex in Normal and Thalassemia Cells

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The Organization of the γ-δ-β Gene Complex in Normal and Thalassemia Cells

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