The new Variant Carbonic Anhydrase in the Japanese: Cainagasaki 1(76 ARG → GLN) and Calhiroshima 2

Abstract

Hemolysates obtained from 4,919 residents of Hiroshima and 4,131 residents of Nagasaki for a total of 9,050 were examined for carbonic anhydrase I (CAI) using vertical starch gel electrophoresis. Eight inherited variants of carbonic anhydrase I, designated CAIHiro-shima 1 (CAIhir 1), were detected and two new fast variants of CAI were detected in one Nagasaki resident and in one Hiroshima resident. These fast variants were designated CAlNagasaki 1 (CAINGS 1) and CAI Hiroshima 2 [CAIhir 2). The isoelectric point of CAIngs 1 was 5.95 and that of CAIhir 2 was 6.20.