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Abstract
Hemoglobin G-San Jose was first discovered by Schwartz et al. in 1957 (1), and its structural abnormality was elucidated in 1959 (2,3). Since then, Ricco et al. (4) observed this variant in members of an Italian family while Musumeci et al. (quoted in 5) discovered a second Italian family with Hb G-San Jose. A blood sample from the propositus of this second family, an adult Sicilian man with Hb G-San Jose-β°-thalassemia, was used for an evaluation of some functional and physicochemical properties of the variant (5). These studies showed that the oxygen affinity and the Bohr effect of Hb G-San Jose, and its polymerization with Hb S were the same as those of Hb A. However, its mechanical precipitation rate was slightly increased while Hb G-San Jose was also slightly more heat labile.