Do Amino Acids Reverse the Sickling of Erythrocytes Containing Hemoglobin S?

Keishiro Shirahama Cardiovascular Research Institute, University of California San Francisco, California, 94143, USA

Shigeo Kubota Cardiovascular Research Institute, University of California San Francisco, California, 94143, USA

Jen Tsi Yang Cardiovascular Research Institute, University of California San Francisco, California, 94143, USA

Abstract

Homoserine, asparagine and glutamine do not restore the de-formability of deoxygenated sickle cells in spite of noticeable morphological changes. These amino acids also do not raise the minimum gelling concentration of deoxyhemoglobin S. The use of these compounds as anti-sickling agents is therefore doubtful.

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Do Amino Acids Reverse the Sickling of Erythrocytes Containing Hemoglobin S?

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Do Amino Acids Reverse the Sickling of Erythrocytes Containing Hemoglobin S?

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