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Hemoglobin
international journal for hemoglobin research
Volume 5, 1981 - Issue 4
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Original Article

Isoelectric Focusing of Globin Chains for Antenatal Diagnosis of β°-Thalassemia

, , , , , , , & show all
Pages 349-356 | Received 29 Apr 1980, Accepted 10 Oct 1980, Published online: 07 Jul 2009
 

Abstract

A recently developed isoelectric focusing technique for human globin chain separation has been applied to the antenatal diagnosis of β°-thalassemia in Sardinia. Results obtained with this method show a complete concordance with those obtained by the currently-in-use chromatographic separation of globin chains by carboxymethyl-cellulose. The ease with which several samples (up to 20) can be simultaneously processed and analyzed by a single operator and the very simple equipment required make this new method ideal for the antenatal diagnosis of β°-thalassemia and could encourage a more widespread use of prenatal diagnosis of thalassemias.

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