Hemoglobin Miyashiro (β 23[B5] Val → Gly) an Electrophoretically Silent Variant Discovered by the Isophopanol Test

T. Nakatsuji Department of Internal Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, 108, Japan

S. Miwa Department of Internal Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, 108, Japan

Y. Dhba Department of Clinical Pathology, Yamaguchi University, Ube, 755, Japan

Y. Hattori Department of Clinical Pathology, Yamaguchi University, Ube, 755, Japan

T. Miyaji Department of Internal Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, 108, Japan

H. Miyata Japan Red Cross Medical Center, 22-1-4, Hiroo, Shibuyaku, Tokyo, 105, Japan

T. Shinohara Japan Red Cross Medical Center, 22-1-4, Hiroo, Shibuyaku, Tokyo, 105, Japan

T. Hori Japan Red Cross Medical Center, 22-1-4, Hiroo, Shibuyaku, Tokyo, 105, Japan

J. Takayama Japan Red Cross Medical Center, 22-1-4, Hiroo, Shibuyaku, Tokyo, 105, Japan

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Abstract

A new unstable hanoglobin was discovered in a Japanese boy without any signs of hemolytic disease during screening of patients by the isopropanol test. The abnormal hemoglobin was found in three generations. This slightly unstable hemoglobin could not be separated from Hb A by electrophoresis. All carriers showed an increased whole blood oxygen affinity. Structural studies demonstrated a previously unreported amino acid substitution, β23[B5] valine → glycine. This new unstable variant has been named Hb Miyashiro.

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Hemoglobin Miyashiro (β 23[B5] Val → Gly) an Electrophoretically Silent Variant Discovered by the Isophopanol Test

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Hemoglobin Miyashiro (β 23[B5] Val → Gly) an Electrophoretically Silent Variant Discovered by the Isophopanol Test

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