A New Unstable Hemoglobin, Hb Yokohama β31(B13)LEU → Pro, Causing Hemolytic Anemia

T. Nakatsuji Department of Internal Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, 108, Japan

S. Miwa Department of Internal Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, 108, Japan

Y. Ohba Department of Clinical Pathology, Yamaguchi University School of Medicine, Ube, 755, Japan

Y. Hattori Department of Clinical Pathology, Yamaguchi University School of Medicine, Ube, 755, Japan

T. Miyaji Department of Clinical Pathology, Yamaguchi University School of Medicine, Ube, 755, Japan

S. Hino Yokohama Teishin Hospital, Yokohama, 221, Japan

N. Matsumoto College of Medical Technology, Yamaguchi University, Ube, 755, Japan

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Abstract

A new unstable hemoglobin was found in a 33-year-old Japanese woman with a history of chronic, partially compensated hemolytic anemia. An electrophoretically silent unstable β chain was prepared by PCMB precipitation and the amino acid substitution determined as β31(B13)Leu → Pro. Her son was a carrier of the same variant, who manifested milder symptoms.

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A New Unstable Hemoglobin, Hb Yokohama β31(B13)LEU → Pro, Causing Hemolytic Anemia

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A New Unstable Hemoglobin, Hb Yokohama β31(B13)LEU → Pro, Causing Hemolytic Anemia

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