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Hemoglobin
international journal for hemoglobin research
Volume 5, 1981 - Issue 7-8
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Original Article

A New Unstable Hemoglobin, Hb Yokohama β31(B13)LEU → Pro, Causing Hemolytic Anemia

, , , , , & show all
Pages 667-678 | Received 07 Jul 1981, Accepted 27 Aug 1981, Published online: 07 Jul 2009
 

Abstract

A new unstable hemoglobin was found in a 33-year-old Japanese woman with a history of chronic, partially compensated hemolytic anemia. An electrophoretically silent unstable β chain was prepared by PCMB precipitation and the amino acid substitution determined as β31(B13)Leu → Pro. Her son was a carrier of the same variant, who manifested milder symptoms.

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