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Hemoglobin
international journal for hemoglobin research
Volume 5, 1981 - Issue 7-8
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Original Article

Hemoglobin Shuangfeng (α27(B8) GLb→LYS): A New Unstable Hemoglobin Variant

Liang Chihchuan Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Beijing, China
,
Tao Hainan Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Beijing, China
,
Lo Hweiyuen Department of Medical Genetics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Beijing, China
,
Huang Shangzhi Department of Medical Genetics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Beijing, China
,
Li Ruiyou Laboratory of Hematology, Army General Hospital of China, Beijing, China
&
Wang Bauseng Department of Medicine, Army Hospital, Liaoning, China
Pages 691-700 | Received 08 Aug 1981, Accepted 25 Sep 1981, Published online: 07 Jul 2009
 
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Abstract

An unstable hemoglobin variant was found in a 24-year-old Chinese of Han origin. It had an electrophoretic mobility slightly faster than that of Hb A2, but could not be separated from it completely by cellulose acetate elec-trophoresis (pH 8.6). Chromatography on a DE-52 column showed that the variant amounted to approximately 13% of the total hemoglobin.

Structural analysis showed that the hemoglobin had the structure α27(B8) Glu→Lys. It was named Hemoglobin Shuangfeng. The α27 Glu residue is an invariable residue located near the α1βl contact.

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