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Hemoglobin
international journal for hemoglobin research
Volume 5, 1981 - Issue 2
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Original Article

Survey of cord blood Hemoglobin in Japan and Identification of two new γ Chain Variants

, , , &
Pages 139-151 | Received 07 Aug 1980, Accepted 10 Oct 1980, Published online: 07 Jul 2009
 

Abstract

Two γ chain variants were discovered during a survey of 2,569 cord bloods of Japanese. One was the first case with mutation of the T-γ; chain, i. e. Hb F Yamaguchi or γ 80 (EF 4) Asp → Asn (75 Thr, 136 Ala). It comprised 33.6 % of Hb F, an unusually high percentage for a γ chain variant. The other concerned with the first report of substitution at E 16, i. e. Hb F Iwata or γ72 (E 16) Gly → Arg (75 Ile, 136 Ala). It comprised 11.0 % which is comparable to the values usually reported in an A-γ chain variant. No clinical consequences have been observed in association with the hemoglobin variants.

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