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Abstract
The solubilities of hemoglobins A and S, reconstituted with various metalloporphyrins, in concentrated phosphate solutions are reported. In HbA the metallo-substituted derivatives have solubilities identical to Fe(11)HbAO2, except for PorHbA, which is less soluble. In HbS the central megal influences the solubility in the order Fe(II)HbS02>Cu(II)HbS> Ni(II)HbS>Zn(II)HbS∼PorphyrinHbS>Fe(II)HbS. The changes in solubility properties of metallo-substituted HbS is probably related to conformational changes which alter interactions among hemoglobin molecules.