Sickle Cell-Hemoglobin Caribbean - A Benign Syndrome

Abstract

The β chain variant Hb Caribbean (β9l LeuàArg) (1) which travels in the position of Hb S on alkaline electrophoresis, was first discovered during a cord blood screening program for the detection of sickle cell disease in Jamaica (2). The propositus, who is a double heterozygote for Hb S and Hb Caribbean has now been followed for seven years. Since it is important to know whether sickle cell-Hb Caribbean represents a form of sickle cell disease or a benign syndrome, the clincal and hematological features of this child from birth to seven years old are reported.