Hemoglobin F-Caltech: α₂Gγ² 120Lys→Gln

Joan B. Shelton Division of Chemistry and Chemical Engineering California Institute of Technology Pasadena, California, 91125, USA

J. Roger Shelton Division of Chemistry and Chemical Engineering California Institute of Technology Pasadena, California, 91125, USA

Zenaida Espinueva Division of Chemistry and Chemical Engineering California Institute of Technology Pasadena, California, 91125, USA

Van Huynh Division of Chemistry and Chemical Engineering California Institute of Technology Pasadena, California, 91125, USA

W. A. Schroeder Division of Chemistry and Chemical Engineering California Institute of Technology Pasadena, California, 91125, USA

Darleen Powars Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, California, 90033

Abstract

During cord blood screening, a fast moving γ-chain variant was detected in an infant of French-Swedish-Hispanic extraction. In this variant, lysine at residue 120(GH 3) in the Gγ chain is replaced by glutamine. Because the AγT chain is also present, this girl has four types of γ chain. The percentage is unusually high for a γ-chain variant.

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Hemoglobin F-Caltech: α₂Gγ² 120Lys→Gln

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Hemoglobin F-Caltech: α₂Gγ² 120Lys→Gln