Hemoglobin Variant with Slight Instability and Increased Oxygen Affinity, Hb Etobicoke [α84 (F5) Ser Arg]: The First Case Detected in Japan

Abstract

A recent hemoglobinopathy survey conducted in Aichi Prefecture disclosed an abnormal hemoglobin which exhibited a slight molecular instability and an increased oxygen affinity. It migrated between the Hb →₂ and Hb A bands on isoelectric focusing of the hemolysate (1). This paper describes the structural and functional character of this hemoglobin.