Hemoglobin Maputo : A New 6-Chain Variant (α₂β₂ 47 (Cd6) Asp→Tyr) in Combination with Hemoglobin S, Identified by High Performance Liquid Chromatography (Hplc)

M. Marinucci Istituto Superiore di Sanita, Viale Regina Elena, 299, ROMA, Italy

J. P. Boissel Institut de Pathologie et Biologie Cellulaires et Moléculaires, INSERM U 15, 24 rue du Fg St Jacques, 75014, PARIS, France

A. Massa Istituto Superiore di Sanita, Viale Regina Elena, 299, ROMA, Italy

H. Wajcman Institut de Pathologie et Biologie Cellulaires et Moléculaires, INSERM U 15, 24 rue du Fg St Jacques, 75014, PARIS, France

L. Tentori Istituto Superiore di Sanita, Viale Regina Elena, 299, ROMA, Italy

D. Labie Institut de Pathologie et Biologie Cellulaires et Moléculaires, INSERM U 15, 24 rue du Fg St Jacques, 75014, PARIS, France

Abstract

During a routine hematological investigation, a slowly-moving hemoglobin variant was detected in a 2-year-old child from Maputo (Mozambique) in combination with hemoglobin S. Structural studies carried out by HPLC demonstrated a previously unreported amino acid substitution, β 47 (CD6) Asp→Tyr. The new hemoglobin variant has been named hemoglobin Maputo.

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Hemoglobin Maputo : A New 6-Chain Variant (α₂β₂ 47 (Cd6) Asp→Tyr) in Combination with Hemoglobin S, Identified by High Performance Liquid Chromatography (Hplc)

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Hemoglobin Maputo : A New 6-Chain Variant (α2β2 47 (Cd6) Asp→Tyr) in Combination with Hemoglobin S, Identified by High Performance Liquid Chromatography (Hplc)

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Hemoglobin Maputo : A New 6-Chain Variant (α₂β₂ 47 (Cd6) Asp→Tyr) in Combination with Hemoglobin S, Identified by High Performance Liquid Chromatography (Hplc)