Hb Albany-GA or α₂ 11(A9)Lys→Asnβ₂

B. B. Webber Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA

H. Lam Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA

J. B. Wilson Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA

T. H. J. Huisman Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA

Abstract

A fast-moving α chain abnormal hemoglobin (Hb J) was observed in a black teenager from southern Georgia. Its guantity, i.e. the sum of Hb J and Hb J₂, was 23.8%. Its presence did not cause any hematological or clinical abnormalities. Tryptic peptides from a digest of the α-J chain were separated by HPLC. Amino acid analysis of these peptides and seguence analysis of the abnormal T-2,3 nonapeptide identified a Lys → Asn substitution at position α11(A9).

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Hb Albany-GA or α₂ 11(A9)Lys→Asnβ₂

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Hb Albany-GA or α2 11(A9)Lys→Asnβ2

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Hb Albany-GA or α₂ 11(A9)Lys→Asnβ₂