Abstract
A fast-moving α chain abnormal hemoglobin (Hb J) was observed in a black teenager from southern Georgia. Its guantity, i.e. the sum of Hb J and Hb J2, was 23.8%. Its presence did not cause any hematological or clinical abnormalities. Tryptic peptides from a digest of the α-J chain were separated by HPLC. Amino acid analysis of these peptides and seguence analysis of the abnormal T-2,3 nonapeptide identified a Lys → Asn substitution at position α11(A9).