HB Hope [3136 (H 14) Gly → Asp] in a Japanese Family

T. Harano Department of Biochemistry and Clinical Pathology, Kawasaki Medical School, Kurashiki, Okayama, 701-01, (Japan)

K. Harano Department of Biochemistry and Clinical Pathology, Kawasaki Medical School, Kurashiki, Okayama, 701-01, (Japan)

S. Ueda Department of Biochemistry and Clinical Pathology, Kawasaki Medical School, Kurashiki, Okayama, 701-01, (Japan)

S. Shibata Department of Biochemistry and Clinical Pathology, Kawasaki Medical School, Kurashiki, Okayama, 701-01, (Japan)

K. Imai Department of Physicochemical Physiology, Medical School, Osaka University, Nakanoshima, Osaka, 530, (Japan)

T. Nakai Department of Biochemistry and Clinical Pathology, Kawasaki Medical School, Kurashiki, Okayama, 701-01, (Japan); Department of Clinical Pathology, Dokkyo Medical College, Mibu-cho, Tochigi, 321-02, (Japan)

Abstract

In April 1982, we encountered a hemolysate having an abnormal hemoglobin band very slightly anodic to Hb A on isoelectric focusing. Structural analysis demonstrated that the hemoglobin was identical to Hb Hope [β136 (H 14) Gly → Asp], which was first found by Minnich et al in an American Negro family in 1965 (1). We report the first observation of Hb Hope in a Japanese family.

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HB Hope [3136 (H 14) Gly → Asp] in a Japanese Family

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