Hemoglobin Minneapolis-Laos [β-118 (GH1) Phe→Tyr] A New Hemoglobin Variant with Normal Functional Properties

Bo Hedlund Department of Pediatrics and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, 55455

Stephenie Paine Department of Pediatrics and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, 55455

Clark M. Smith Department of Pediatrics and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, 55455

John Raines Community/University Health Care Center Health Sciences, 2016 16th Avenue South, Minneapolis, MN, 55404

W. Tully Morrison Departments of Medicine and Biochemistry, Veterans Administration Medical Center, 1500 East Woodrow Wilson Avenue, Jackson, MS, 39216

Junius Adams Departments of Medicine and Biochemistry, Veterans Administration Medical Center, 1500 East Woodrow Wilson Avenue, Jackson, MS, 39216

Abstract

Routine screening of hemoglobin samples from Southeast Asian immigrants by isoelectric focusing (1) revealed an individual with an abnormal hemoglobin component which migrated with approximately the same mobility as fetal hemoglobin. The proband was a 27 year old male of Laotian origin. His newborn son was found to be heterozygous for this variant and HbE. The proband's wife was homozygous for HbE. The proband's hematological findings were as follows: RBC -5.13 million, PCV -48.8%, MCV 95 fl, and Hb -16.7 g/dl. His red cells were normochromic and normocytic.

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Hemoglobin Minneapolis-Laos [β-118 (GH1) Phe→Tyr] A New Hemoglobin Variant with Normal Functional Properties

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Hemoglobin Minneapolis-Laos [β-118 (GH1) Phe→Tyr] A New Hemoglobin Variant with Normal Functional Properties

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