Hemoglobin G Waimanalo: α64 (E13) Aspartic Acid + Asparagine Observed in a Japanese Family

Abstract

Hemoglobin G Waimanalo, in which an asparagine residue is substituted for an aspartic acid at position 64 (E13) of the a-chains, was found in a Japanese family. The propositus was a 40-year-old man with normal hematological parameters. Electro-phoresis of the hemolysates on a cellulose acetate sheet detected a hemoglobin variant that migrated slower than Hb A. The relative mobility was -4.88 at pH 8.6 (1). The variant, Hb A₂, and Hb F comprised 24.1%, 2.0%, and 1% of the total hemoglobins, respectively (2).