Hb himeji or β140 (H18) ALA→ASP a slightly unstable hemoglobin with increased βN-terminal glycation

Y. Ohba Department of Clinical Laboratory Science Yamaguchi, University School of Medicine, 1144 Kogushi, Ube, 755, Japan

T. Miyaji Department of Clinical Laboratory Science Yamaguchi, University School of Medicine, 1144 Kogushi, Ube, 755, Japan

M. Murakami The 3rd Department of Internal Medicine

S. Kadowaki The 3rd Department of Internal Medicine

T. Fujita The 3rd Department of Internal Medicine

M. Oimomi Department of Internal Medicine Kobe, University School of Medicine, 7-5-1, Kusunoki Chuo-ku, Kobe, 650

H. Hatanaka Department of Internal Medicine Kobe, University School of Medicine, 7-5-1, Kusunoki Chuo-ku, Kobe, 650

K. Ishikawa Department of Internal Medicine Kobe, University School of Medicine, 7-5-1, Kusunoki Chuo-ku, Kobe, 650

S. Baba Department of Internal Medicine Kobe, University School of Medicine, 7-5-1, Kusunoki Chuo-ku, Kobe, 650

K. Hitaka Department of Biochemistry, Kurashiki Medical School, 577, Matsushima, Kurashiki, 701-01

K. Imai Department of Physicochemical Physiology Medical School, Osaka University, 4-3-57, Nakanoshima Kita-ku, Osaka, 530

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Abstract

A fast-moving abnormal hemoglobin found in a diabetic patient was identified as β140 (H18) ALA→ASP. It comprised about 40 % of the total hemoglobin. The β-terminal glycation in the abnormal hemoglobin was estimated to be 3 times as much as that in Hb A in the same blood sample. The abnormal hemoglobin was slightly unstable. Oxygen affinity of the stripped hemoglobin was decreased, but that of red cells from the carrier was slightly higher than normal because of the reduced effect of 2,3-diphosphoglycerate.

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Hb himeji or β140 (H18) ALA→ASP a slightly unstable hemoglobin with increased βN-terminal glycation

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Hb himeji or β140 (H18) ALA→ASP a slightly unstable hemoglobin with increased βN-terminal glycation

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