Complete Amino Acid Sequence of γ Chain of Fetal Hemoglobin of Japanese Macaque (Macaca fuscata)

Abstract

The complete amino acid sequence of the γ chain of Japanese macaque(Macaca fuscata) was deduced from sequence analysis of its tryptic peptides and a few other peptides. Three amino acid residues are substituted compared to the human γ chain, 77His(human) to 77Asn (Japanese macaque), 104Lys to 104Arg and 135Thr to 135 Ala. The primary structure of the γ chain of Japanese macaque is the same as that of rhesus macaque(Macaca mulatta)(2) and yellow baboon(papio cynocephalus)(3). Difference in the structure of the γ chain among primate species is smaller than that of β chain.