The Identification of Five Rare β-Chain Abnormal Hemoglobins by High Performance Liquid Chromatographic Procedures

J. B. Wilson Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA

S. S. Chen Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA

B. B. Webber Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA

A. Kutlar Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA

F. Kutlar Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA

A. Villegas Servicio de Hematologia, Hospital Clinico de San Carlos, Madrid, 3, Spain

T. H. J. Huisman Laboratory of Protein Chemistry and Comprehensive Sickle Cell Center, Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA

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Abstract

The detection, quantitation, and characterization of five relatively rare β chain abnormal hemoglobins mainly by high performance liquid chromatographic procedures are described. The variants involved are Hb City of Hope (β69 Gly→Ser), Hb Austin (β 40 Arg→Ser), Hb Leiden (β6 or 7 Glu→O), Hb Louisville (β 42 Phe→Leu), and Hb Presbyterian (β108 Asn→Lys). Some clinical and hematological data are also included.

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The Identification of Five Rare β-Chain Abnormal Hemoglobins by High Performance Liquid Chromatographic Procedures

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The Identification of Five Rare β-Chain Abnormal Hemoglobins by High Performance Liquid Chromatographic Procedures

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