HB F-Xin-Su or ^Aγ^T73(E17)Asp→His: A New Slow-Moving Fetal Hemoglobin Variant

M. Ma Department of Biology, Xinjiang Medical College Urumqi, Xinjiang Uygur Autonomous Region People's, Republic of China

H. Hu Department of Biology, Xinjiang Medical College Urumqi, Xinjiang Uygur Autonomous Region People's, Republic of China

F. Kutlar Department of Cell and Molecular Biology Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, GA, 30912-3331, USA

J. B. Wilson Department of Cell and Molecular Biology Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, GA, 30912-3331, USA

T. H. J. Huismn Department of Cell and Molecular Biology Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, GA, 30912-3331, USA

Abstract

A slow-moving y chain variant was discovered in the cord blood of an infant born to parents of the Han nationality from Jiangsu. The variant, which migrated electrophoretically at alkaline pH between Hb A and Hb D, was characterized by an Asp→His substitution at γ 73, while residues γ75 and γ136 were occupied by Ile and Ala, respectively. As the ^Aγ^T-chain was also present, this baby has two types of abnormal γ-chain. The variant was named Hb F-Xin-Su.

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HB F-Xin-Su or ^Aγ^T73(E17)Asp→His: A New Slow-Moving Fetal Hemoglobin Variant

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HB F-Xin-Su or AγT73(E17)Asp→His: A New Slow-Moving Fetal Hemoglobin Variant

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HB F-Xin-Su or ^Aγ^T73(E17)Asp→His: A New Slow-Moving Fetal Hemoglobin Variant