A new Case of Hb Little Rock [β143(H21)His → Gln], a high affinity variant. Study during pregnancy

A. Francina Unité des Hémoglobines, Ho˘pital Edouard Herriot, 69374, Lyon Cedex, 08, France

C. Lacombe INSERM U 91, Hoptal Henri Mondor, 94010, Créteil, France

F. Baklouti CNRS UA 1171, Faculté de Méd'cine Grange Blanche, 69373, Lyon Cedex, 08, France

E. Dorléac Unité des Hémoglobines, Ho˘pital Edouard Herriot, 69374, Lyon Cedex, 08, France

J. Delaunay CNRS UA 1171, Faculté de Méd'cine Grange Blanche, 69373, Lyon Cedex, 08, France

G. Souillet Hématologic Pédiatrique, Ho˘Dital Debrousse, 69322, Lyon Cedex, 01, France

R. C. Rudigoz Clinique Obstétricale, Ho˘pital Fdouard Herriot, 69374, Lyon Cedex, 08, France

N. Arous INSERM U 91, Hoptal Henri Mondor, 94010, Créteil, France

J. Rosa INSERM U 91, Hoptal Henri Mondor, 94010, Créteil, France

F. Galacteros INSERM U 91, Hoptal Henri Mondor, 94010, Créteil, France

show all

Abstract

A new case of Hb Little Rock [βl43(H21)His → G1n] is described. This high affinity variant (P₅₀ = 15 mm Hg in whole cells) has a nearly normal cooperativity. The abnormal β chain is readily detectable using urea-Triton X-100 electrophoresis. The altered βT-14 peptide was separated by high performance liquid chromatography. The proposita was followed during a pregnancy. Oxygen unloading was reduced, but normal oxygen loading was maintained in the fetus. There were neither placental abnormalities, nor intrauterine growth retardation.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

A new Case of Hb Little Rock [β143(H21)His → Gln], a high affinity variant. Study during pregnancy

Information for

Open access

Opportunities

Help and information

A new Case of Hb Little Rock [β143(H21)His → Gln], a high affinity variant. Study during pregnancy

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature