The Relationship Between HB Bart's Levels in Cord Blood and the Deletions of α-Globin Genes

W. Zhao Department of Pediatrics, Children's. Hospital of Chongging University of Medical Science, Chongging, Sichuan, PR China

J. Zhang Department of Pediatrics, Children's. Hospital of Chongging University of Medical Science, Chongging, Sichuan, PR China

N. S. Wang Department of Pediatrics, Children's. Hospital of Chongging University of Medical Science, Chongging, Sichuan, PR China

P. Deng Department of Pediatrics, Children's. Hospital of Chongging University of Medical Science, Chongging, Sichuan, PR China

Abstract

A relationship between Hb Bart's levels in cord blood and the number of α-globin genes has been established by screening cord blood samples from 1,075 newborn babies. Diagnosis was made by gene mapping of DNA samples with restriction endonuclease digestion. The presence of Hb Bart's was determined with a discontinuous microelectrophoresis on cellulose acetate at pH 8.34. The establishment of this relationship allows an early diagnosis of α-thalassemia by this simple microelectrophoretic procedure.

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The Relationship Between HB Bart's Levels in Cord Blood and the Deletions of α-Globin Genes

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The Relationship Between HB Bart's Levels in Cord Blood and the Deletions of α-Globin Genes

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