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Hemoglobin
international journal for hemoglobin research
Volume 12, 1988 - Issue 1
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Original Article

HB J-Cordoba [α2Aβ2 95 (FG2)LYS →MET] A New HB Variant Found in Argentina

J. Bardakdjian INSERM, U.91, UA CNRS 607, Hp Henri Mondor, 94010, Créteil, France
,
J. Kister INSERM, U.299, Hopital de Bicětre, 94275, Le Kremlin Bicětre, France
,
M. D. Rhoda INSERM, U.91, UA CNRS 607, Hp Henri Mondor, 94010, Créteil, France
,
M. Marden INSERM, U.299, Hopital de Bicětre, 94275, Le Kremlin Bicětre, France
,
N. Arous INSERM, U.91, UA CNRS 607, Hp Henri Mondor, 94010, Créteil, France
,
J. De Leon Centro Hematologico Privato Jujuy, 125 5000, Cordoba, Argentina
,
M. L. North Centre Régional de Transfusion Sanguine, 67085, Strasbourg, France
,
C. Lacombe INSERM, U.91, UA CNRS 607, Hp Henri Mondor, 94010, Créteil, France
,
Y. Blouqui INSERM, U.91, UA CNRS 607, Hp Henri Mondor, 94010, Créteil, France
,
C. Castracane Centro Hematologico Privato Jujuy, 125 5000, Cordoba, Argentina
,
J. Riou INSERM, U.91, UA CNRS 607, Hp Henri Mondor, 94010, Créteil, France
,
J. Rosa INSERM, U.91, UA CNRS 607, Hp Henri Mondor, 94010, Créteil, France
&
F. Galacteros INSERM, U.91, UA CNRS 607, Hp Henri Mondor, 94010, Créteil, France
 show all
Pages 1-11 | Received 06 Jun 1987, Accepted 10 Dec 1987, Published online: 07 Jul 2009
 
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Abstract

Hb J-Cordoba [α2Aβ295(FG2)Lys→Met], is one of the few hemoglobin variants discovered in Argentina. The structure and functional abnormalities are described. Hb J-Cordoba exhibits a slightly increased oxygen affinity, low cooperativity, and normal interaction with heterotropic cofactors.

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