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Hemoglobin
international journal for hemoglobin research
Volume 12, 1988 - Issue 1
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Original Article

The Effect of Oxygen on in Vitro Studies on Kethemoglobin Production in Man and Dog Blood Using 4-Dimethylatiinophenol

A. C. Woodman Medical Division Chemical Defence Establishment Porton Down, Salisbury, Wiltshire, SP4 OJQ, UK
,
J. E. Bright Medical Division Chemical Defence Establishment Porton Down, Salisbury, Wiltshire, SP4 OJQ, UK
&
T. C. Marrs Medical Division Chemical Defence Establishment Porton Down, Salisbury, Wiltshire, SP4 OJQ, UK
Pages 53-60 | Received 11 Aug 1987, Accepted 03 Dec 1987, Published online: 07 Jul 2009
 
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Abstract

Methemoglobin production induced by the addition of 4-dimethylaminophenol to human or beagle blood in vitro is inhibited at high oxyhemoglobin levels. The effect is similar in the two species and probably results from conformational change in hemoglobin consequent on oxygen binding.

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