Hehoglobin Brest [β127(H5)Gln→LYS] a new Unstable Human Hemoglobin Variant Located at the α1β1 Interface with Specific Electrophoretic Behavior

V. Baudin-Chich INSERM, U299, 78 rue du Général Leclerc 94275, Le Kremlin-Bicětre, France

H. Wajcman INSERM, U299, 78 rue du Général Leclerc 94275, Le Kremlin-Bicětre, France

G. Gonbaud-Saintonge INSERM, U299, 78 rue du Général Leclerc 94275, Le Kremlin-Bicětre, France

N. Arous INSERM, U91, Hopital Henri Mondor, 94010, Créteil, France

J Riou Laboratoire Biochimie, Hopital Henri Mondor, 94010, Creteil, France

J. Brière Service d'Hématologie, Hopital Morvan, Brest, France

F. Galacteros INSERM, U91, Hopital Henri Mondor, 94010, Créteil, France

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Abstract

Hb Brest [β127(H5)Gln→Lys] is a new unstable variant located at the α1β1 interface at the same position as Hb Complutense [β127 (H5)Gln→Glu]. In each of these, the substitution produces a distinct alteration in charge, yet both variants move with Hb A in conventional electrophoresis. This peculiar electrophoretical behavior may be due to the molecular position of the modified residue, which is deeply buried inside the tetramer.

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Hehoglobin Brest [β127(H5)Gln→LYS] a new Unstable Human Hemoglobin Variant Located at the α1β1 Interface with Specific Electrophoretic Behavior

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Hehoglobin Brest [β127(H5)Gln→LYS] a new Unstable Human Hemoglobin Variant Located at the α1β1 Interface with Specific Electrophoretic Behavior

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