Which Psychosocial Factors are Related to Chelation Adherence in Thalassemia? A Systematic Review

Abstract

Good adherence to iron chelation therapy in thalassemia is crucial. Although there is evidence that adherence is related to regimen factors, there has been less emphasis on the relationship between psychosocial (psychological, demographic and social) factors and adherence. We present a systematic review of psychosocial correlates of chelation adherence in thalassemia. Nine studies met the inclusion criteria. Information was extracted regarding the study characteristics and the relationship between psychosocial factors and chelation adherence. Methodological quality was rated. The studies took place in a range of countries, were mostly cross sectional in design, and examined adherence to deferoxamine (DFO) only. Sample sizes ranged from 15 to 1573. A variety of psychosocial variables were examined. Definitions of adherence varied between studies and non adherence rates were also variable (9 to 66%). Older age was consistently associated with lower levels of chelation adherence. There were few other consistent findings. The methodological quality of studies was variable. There is a need for more methodologically sophisticated and theoretically informed studies on psychosocial correlates of chelation adherence. We offer specific suggestions.

Keywords:

• Adherence
• Chelation
• Thalassemia
• Psychosocial
• Systematic review

ACKNOWLEDGMENTS

We would like to acknowledge the help of Davide Crepaldi and Kristin Bohn (Royal Holloway, University of London, Egham, Surrey, UK) in the translation of papers in Italian and German, respectively.

Declaration of Interest:The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.