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Hemoglobin
international journal for hemoglobin research
Volume 35, 2011 - Issue 4
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Short Communications

Early Prenatal Diagnosis of Thalassemia: The First Report of Experience in Mainland China

, , , , , & show all
Pages 434-438 | Received 04 Dec 2010, Accepted 20 Jan 2011, Published online: 28 Jul 2011
 

Abstract

In this study, we report our experience with chorionic villus sampling (CVS) for prenatal diagnosis of thalassemia in mainland China. During a 4-year period, 308 pregnant women chose to have CVS for prenatal diagnosis. Chorionic villus sampling was successful in all cases, and post-CVS abortion was seen in only two cases (0.6%). DNA diagnosis was correctly done in 307 (99.7%) prenatal samples but maternal contamination was found in one (0.3%) subject. In total, 77 pregnancies were found with an affected fetus, and all of the affected pregnancies were terminated within 1 week after the CVS procedure. Our experience indicates that CVS is a feasible and effective technique for prenatal diagnosis of thalassemia.

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