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Hemoglobin
international journal for hemoglobin research
Volume 36, 2012 - Issue 4
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Original Article

Newborn Screening Shows a High Incidence of Sickle Cell Anemia in Central India

, , , , , & show all
Pages 316-322 | Received 27 Dec 2011, Accepted 29 Feb 2012, Published online: 19 Jun 2012
 

Abstract

There is limited data on the incidence of sickle cell anemia in Central India; we therefore conducted a study to estimate the incidence of this disease in Central India. Mothers who delivered a live baby at the Government Medical College, Nagpur, India were screened for the presence of the sickle cell hemoglobin {Hb S: [β6 (A3) Glu →Val, GAG >GTG]} using the solubility test within 48 hours of delivery. Infants of mothers who showed the presence of Hb S then underwent Hb analysis by high performance liquid chromatography (HPLC). A total of 8243 mothers was screened, 1178 of whom were positive. One thousand, one hundred and sixty-two infants of mothers with a positive solubility test underwent Hb analysis by HPLC; 530 infants were normal, while 536 were heterozygous for Hb S (sickle cell trait), 88 babies were homozygous for Hb S (sickle cell anemia), while another eight babies had other Hb abnormalities. The incidence of sickle cell anemia was highest in the Scheduled caste group (1:50). We concluded that the incidence of sickle cell anemia is high in central India.

ACKNOWLEDGMENTS

The present study was funded by the Department of Biotechnology, Ministry of Sciences and Technology, New Delhi, India.

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