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Thalassemia screening usually involves cut-off values based on a mean corpuscular volume (MCV) of less than 80 fL or a mean corpuscular hemoglobin (MCH) of less than 27 pg. These strategies are able to detect almost all heterozygous carriers of the α-thalassemia (α-thal) (– –SEA) deletion in the Chinese population. However, an exception can occur. We describe an α0-thal trait with normal red cell indices in two Chinese individuals.
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