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Hemoglobin
international journal for hemoglobin research
Volume 37, 2013 - Issue 2
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Original Article

Hb Treviso [α91(FG3)Leu→Phe (α2)]: A New Slightly Unstable Hemoglobin Variant with Moderately Decreased Oxygen Affinity

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Pages 107-111 | Received 20 Aug 2012, Accepted 20 Sep 2012, Published online: 25 Jan 2013
 

Abstract

We report a new hemoglobin (Hb) variant, found in a North-East Italian family living in the city of Treviso. The proband, a non anemic 60-year-old male with a history of chronic rhinitis, allergy to Parietaria and suspected obstructive sleep apnea syndrome, was referred for blood gas analysis. Determination of the oxygen affinity revealed a p50 of 32.5 mmHg (control 27.5 mmHg) indicating a moderate decrease in oxygen affinity. An abnormal pattern compatible with an α Hb variant was observed on high performance liquid chromatography (HPLC); direct sequencing revealed a transition at codon 91 of the α2 gene (HBA2: c.274C>T) changing leucine into phenylalanine. Characterization and phenotype studies are reported.

ACKNOWLEDGMENTS

All patients gave explicit permission for this study which was conducted according to the local medical ethical regulations.

Declaration of Interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

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