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Hemoglobin
international journal for hemoglobin research
Volume 37, 2013 - Issue 2
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Short Communication

Detection of Hb Constant Spring [α142, Term→Gln, TAA>CAA (α2)] in Heterozygotes Combined With β-Thalassemia

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Pages 197-200 | Received 06 Sep 2012, Accepted 04 Oct 2012, Published online: 08 Feb 2013
 

Abstract

Hb Constant Spring [Hb CS, α142, Term→Gln, TAA>CAA (α2)] is a nondeletional form of α-thalassemia (α-thal) that is most prevalent in Southern Chinese and Southeast Asian populations. We previously found that Hb CS trait could efficiently be screened using Sebia Capillarys2. In this study, we report that Hb CS heterozygotes combined with β-thal could not be detected by the Sebia Capillarys2 method due to the very small amount of Hb CS.

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