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Hemoglobin
international journal for hemoglobin research
Volume 37, 2013 - Issue 6
64
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Short Communication

Hb Papanui [α99(G8)Lys→Arg; HBA2: c.299A>G]: A Novel Silent Substitution Interfering in Hb A1c Determination

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Pages 589-592 | Received 29 Jan 2013, Accepted 04 Mar 2013, Published online: 28 Jun 2013
 

Abstract

We report a novel hemoglobin (Hb) mutation [Hb Papanui [α99(G8)Lys→Arg; HBA2: c.299A>G] that was identified in an individual with an inappropriately low Hb A1c value of 2.8% when using an ion exchange method. Although occurring at a well conserved site, the conservative substitution was not associated with any adverse clinical features.

ACKNOWLEDGMENTS

We wish to thank Anthea Povall and Charles Hawes (Canterbury Health Laboratories, Christchurch, New Zealand) for technical assistance.

Declaration of Interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

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