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Hemoglobin
international journal for hemoglobin research
Volume 40, 2016 - Issue 2
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Short Communication

Hb Matera (HBB: c.167 T > A): A Second Case Detected in a Pregnant Chinese Woman by the Capillary Electrophoresis Method

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Pages 125-126 | Received 13 Jul 2015, Accepted 01 Sep 2015, Published online: 25 Feb 2016
 

Abstract

Hb Matera (HBB: c.167 T > A) is an unstable β-globin gene variant with an ATG > AAG substitution at codon 55. Its coelution with Hb A2 on high performance liquid chromatography (HPLC) makes it difficult to discriminate between Hb Matera and Hb E (HBB: c.79 G > A) that also coelutes with Hb A2 in this method. However, we found that capillary electrophoresis (CE) was able to detect Hb Matera and discriminate it from Hb E, based on the quantification of the peaks and on hematological parameters.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

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